HGH Fragment 176-191 - 5mg Ipamorelin - 5mg 10mg Total Compounds Per Vial 10ml of Bacteriostatic Water For Reconstitution Included
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS), structurally derived from ghrelin, that selectively agonizes the growth hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons. It induces a dose-dependent release of endogenous growth hormone (GH) with minimal impact on other pituitary hormones, distinguishing it from non-selective GHSs. Physiological Roles (Ipamorelin)
Selective GH Secretion: Ipamorelin promotes pulsatile GH release, enhancing downstream insulin-like growth factor-1 (IGF-1) production in the liver, which supports anabolic effects including protein synthesis, lipolysis, and connective tissue repair without significant cortisol or prolactin elevation.
Neuroendocrine Modulation: It exhibits appetite-neutral properties compared to ghrelin mimetics, potentially aiding in metabolic regulation and recovery from catabolic stress, such as in postoperative or athletic contexts.
Human Growth Hormone (hGH) Fragment 176-191 is a 16-amino acid synthetic peptide corresponding to the C-terminal region of the 191-amino acid hGH molecule. This truncated analog retains lipolytic properties while lacking the full mitogenic and hyperglycemic effects of intact hGH, making it a targeted agent for adipose tissue modulation. Physiological Roles (HGH Fragment)
Lipolytic Activity: The fragment binds to β3-adrenergic receptors on adipocytes, stimulating cyclic AMP production and hormone-sensitive lipase activation, which promotes fatty acid oxidation and inhibits lipogenesis, selectively reducing visceral and subcutaneous fat mass.
Metabolic Effects: It supports glucose homeostasis without inducing insulin resistance, potentially enhancing energy expenditure and body composition in the absence of GH-mediated growth promotion.
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