10ml of Bacteriostatic Water For Reconstitution Included
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified analog of native IGF-1. It features an N-terminal extension and an amino-acid substitution that reduces binding to IGF-binding proteins. This results in a longer half-life and greater bioavailability at the IGF-1 receptor compared with native IGF-1 in research models. It is a single-chain polypeptide engineered for enhanced anabolic signaling.
Physiological Roles
Anabolic and Mitogenic Effects: IGF-1 LR3 binds to IGF-1 receptors (IGF-1R) on target cells, activating the PI3K/Akt and MAPK/ERK pathways. This supports cell proliferation, differentiation, survival, and hypertrophy. Research models show it promotes muscle protein synthesis and tissue growth with higher potency than native IGF-1 due to reduced binding-protein interference.
Metabolic Regulation: Enhances glucose uptake and glycogen synthesis in skeletal muscle, supports nutrient partitioning, and modulates protein metabolism. These actions contribute to recovery, tissue repair, and cellular energy utilization in experimental settings.
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