4mg Total Compounds Per Vial 10ml of Bacteriostatic Water For Reconstitution Included
Insulin-like growth factor 1 (IGF-1) is a 70-amino acid single-chain polypeptide hormone structurally related to proinsulin, with three intramolecular disulfide bridges. Mecasermin is the recombinant human form (rhIGF-1). Circulating IGF-1 is predominantly liver-derived under growth hormone (GH) stimulation, with autocrine/paracrine production in multiple tissues.
Physiological Roles
Anabolic and Mitogenic Effects: IGF-1 binds to IGF-1 receptors (IGF-1R) on target cells, activating the PI3K/Akt and MAPK/ERK pathways to promote cell proliferation, differentiation, survival, and hypertrophy. It mediates many GH-dependent actions, including linear skeletal growth via chondrocyte stimulation in epiphyseal plates.
Metabolic Regulation: Enhances glucose uptake and glycogen synthesis in skeletal muscle and adipocytes, suppresses hepatic gluconeogenesis, and modulates protein metabolism, thereby supporting tissue repair, bone mineralization, and immune function.
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